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Home » Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022

Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022

Silver Sulfadiazine Cream - Uses, Side Effects, medication work 2022

Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022

Silver sulfadiazine belongs to the family of medications called topical antibiotics. It is used to treat and prevent infections of skin wounds, especially for victims of severe burns. It can also be used for leg ulcers, skin grafts, surgical incisions, and minor cuts and scrapes. It is applied directly to the affected area and works by stopping the action of bacteria that can cause infection.

Your doctor may have suggested this medication for a condition not listed in this medication information article. Also, some forms of this medication may not be used for all of the conditions mentioned in this article. If you haven’t discussed this with your doctor yet, or you’re not sure why you’re using this medication, check with your doctor. Do not stop using this medication without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.

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What forms does this medication come in?

Flamazine is a white cream containing 1% w/w silver sulfadiazine. Nonmedicinal ingredients: cetyl alcohol, distilled water, glyceryl stearate, liquid paraffin, polysorbate 60, polysorbate 80, and propylene glycol.

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How should this medicine be used?

Burns: clean the burn and apply a layer of silver sulfadiazine to a thickness of 3 mm to 5 mm over the entire affected surface.

One technique is to apply the cream with a sterile glove or a sterile non-metallic spatula. If necessary, reapply the cream to areas where it has disappeared following movement. Reapply the cream every 24 hours at least.

When it comes to treating lesions inflicted by burns or wounds to the skin of the hand and fingers, one of the recommended methods is to apply the medicine to the affected part and then to put the hand in a bag made of transparent plastic or a glove, which will be kept tight on the wrist. Change the dressing every three days or whenever many fluids have passed into the bag.

Silver sulfadiazine cream is also used in the treatment of leg ulcers. Clean the leg ulcer and fill the cavity with a layer of silver sulfadiazine at least 3 mm to 5 mm thick. Avoid applying silver sulfadiazine to the area around the wound. Apply the appropriate dressing and change it every 2 or 3 days.

Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022

Ask your healthcare professional about the best way to apply the cream and treat the affected area.

Several factors can be taken into account to determine the dose a person needs: their weight, their state of health, and the taking of other medicines. If your doctor has recommended a dose other than those listed here, do not change how you take medicine without consulting your doctor first.

This medicine must be used exactly as prescribed by your doctor. If you forget a dose, apply for the medicine as soon as you notice the omission and resume the rest of the treatment as soon as possible. If it is almost time for your next dose, don’t worry about the missed dose and return to the usual dosing schedule. Do not apply a double dose of the medicine to make up for missing a dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

Store this medication at room temperature and out of the reach of children.

Do not dispose of medicines in the wastewater (e.g., not in the sink or the toilet bowl) or with the household waste. Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this medication not recommended?

Silver sulfadiazine should not be used in the following circumstances:

  • an allergy to silver sulfadiazine or any of the ingredients of the medicine;
  • a full-term pregnant woman;
  • a premature or a newborn during the first months of life;
  • concurrent treatment with sulfonamides.

What are the possible side effects of this drug?

Many medications can cause side effects. A side effect is an adverse response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medication have reported the following side effects. Many of these side effects are manageable, and a few may go away on their own over time.

Consult your doctor if you experience these side effects and if they are severe or bothersome. Your pharmacist may be able to advise you on what to do if these side effects appear:

  • a burning sensation on the treated area;
  • itching or rash.

Most of the side effects listed below do not happen very often, but they could cause serious problems if you do not see your doctor or get medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • the appearance of blisters, peeling or peeling of the skin;
  • enlarged lymph nodes;
  • burns that trigger intense itching;
  • pain from the treated area;
  • shortness of breath;
  • unusual tiredness or weakness;
  • chills, or fever;
  • red skin lesions with a purplish center;
  • sores, ulcers, or white patches on the lips or inside the mouth;
  • sore throat;
  • the skin takes on an ashen color;
  • unusual bleeding or bruising;
  • increased sensitivity of the skin to solar radiation, especially for people with burns affecting a large area of ​​the body;
  • signs of kidney damage (e.g., less frequent urination, less frequent urination, painful urination, swelling, fatigue, abdominal pain);
  • Bloody or cloudy urine.

Some people may experience side effects other than those listed. Consult your doctor if you notice any symptom that worries you while using this medication.

Are there any other precautions or warnings?

Before using any medication, tell your doctor about any medical conditions or allergies you may have, the medications you use, and any other important facts about your health. Women should mention if they are pregnant or breastfeeding. These factors may influence how you should use this medicine.

Sulfonamide allergy: Some people who are allergic to sulfonamide antibiotics like sulfamethoxazole also experience allergic reactions when using silver sulfadiazine. Before using this medication, tell your doctor about any adverse reactions while using other antibiotics. Contact your doctor immediately if you experience an allergic reaction such as rash, itching, difficulty breathing, or swelling of the face and throat.

Glucose-6-phosphate dehydrogenase deficiency: People with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency should use silver sulfadiazine with caution due to the risk of hemolysis (destruction of blood cells).

Hepatic and renal functions: silver sulfadiazine should be used with caution by people with significant hepatic or renal insufficiency. If you use this medication to treat large wounds, you must drink plenty of fluids to prevent dehydration and kidney damage.

Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022

Oral Hypoglycemics and Phenytoin: Antidiabetic agents and phenytoin may have an enhanced effect when given to persons with extensive burns whose serum sulfadiazine levels may approach therapeutic levels. Therefore, it is recommended that medical monitoring targeting their blood levels be carried out.

Overgrowth of organisms: Antibiotic use occasionally leads to the overgrowth of microorganisms not killed by the antibiotic, such as bacteria, fungi, and other microorganisms. Other infections may follow, such as yeast infections. Contact your doctor if you experience any new symptoms while using silver sulfadiazine.

Pregnancy: The safety of silver sulfadiazine during pregnancy has not been established. Silver sulfadiazine should only be used for a pregnant woman with severe burns if the benefits outweigh the risks. It should not be used near the end of pregnancy.

Breastfeeding: This medication passes into breast milk. If you use silver sulfadiazine while breastfeeding, your baby may feel the effects. Consult your doctor to find out if you should continue breastfeeding.

Can other agents interact with this drug?

There may be an interaction between silver sulfadiazine and any of the following agents:

  • enzymatic debridement agents,
  • cimetidine,
  • antidiabetic drugs,
  • phenytoin;
  • sodium picosulphate
  • the BCG tuberculosis vaccine;
  • the cholera vaccine.

If you are taking any of these medicines, consult your doctor or pharmacist. In your case, your doctor may ask you to:

  • stop taking any of the medications,
  • replacing one of the drugs with another,
  • change the way you take one or both of the medicines
  • change nothing at all.

The interference of one drug with another does not always lead to discontinuing taking one of them. Ask your doctor what to do in case of drug interactions.

Medications other than those listed above may interact with this medication. Tell your doctor about everything you take, including prescription and over-the-counter medications and herbal remedies. Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or illicit drugs, you should inform your prescribing doctor since these substances can modify the action of many drugs.

The indications of Silver Sulfadiazine Cream antibacterial cream ( silver sulfadiazine ) have been restricted: 

Silver Sulfadiazine Cream – Uses, Side Effects, medication work 2022
  • adults and children over two months old, 
  • in the prevention and treatment of infections in the management of burns from the second degree. 

Silver Sulfadiazine Cream is no longer indicated for the adjunctive treatment of dermatological conditions that are primarily bacterial or susceptible to secondary infection: the therapeutic benefit of silver sulfadiazine has not been demonstrated in this indication, according to the reassessment of the benefit-risk balance of this drug, conducted by the ANSM. 

The contraindication of Silver Sulfadiazine Cream in infants under two months considers the risk of systemic passage exposure to potential general complications of sulfonamides. This risk must be taken into account in children up to 2 years of age. 

Finally, FLAMMAZINE is now contraindicated during breastfeeding children under one month or presenting a G6PD deficiency. 

During pregnancy, 

A second-degree burn is defined by the appearance of a blister (illustration).

Specialty silver sulfadiazine, available in France on compulsory medical prescription (a list I), FLAMMAZINE has been the subject of a reassessment of its benefit/risk ratio, which has led to a review of the scope of indications and use of this antibacterial cream in certain populations. 

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FLAMMAZINE, only for burns 

Safety information dated the Medicines Agency (ANSM) states that FLAMMAZINE cream should only be used in adults and children over two months of age to prevent and treat infections in the context of the management of burns from the second degree. 

The indication of FLAMMAZINE in the t Adjunctive treatment of dermatological conditions primarily bacterial or likely to become superinfected has been withdrawn due to the lack of demonstration of a clinical benefit. No methodologically rigorous comparative study versus placebo or active treatment was identified. 

No FLAMMAZINE in infants under two months

In addition, the reassessment of FLAMMAZINE led to its use being restricted in pediatrics: FLAMMAZINE cream is now contraindicated in children under two months (premature, newborn, infant under two months).

In children under two years of age, it should be used with caution due to the increased risk of systemic passage in this age category, which exposes people to potential systemic complications from sulfonamides.

FLAMMAZINE in pregnant or breastfeeding women: caution

In pregnant women, FLAMMAZINE is possible as the last intention, i.e., only in the absence of a therapeutic alternative. This recommendation must be particularly respected during the 3rd month of pregnancy because of a potential risk of severe, even nuclear, jaundice in the newborn by displacement of bilirubin. 

Since sulfadiazine passes into breast milk, FLAMMAZINE is also contraindicated during breastfeeding:

  • if the child is less than one month old because of the immaturity of the enzyme system in this population and the consequent risk of kernicterus;
  • If the child has a G6PD deficiency, to prevent the occurrence of hemolysis.

Duration of treatment limited to 15 days in the absence of benefit

Burns that have not healed after 15 days of treatment with FLAMMAZINE must be the subject of medical advice from a hospital care service specializing in managing a load of burns. 

To go further

Flammazine (silver sulfadiazine cream): do not use on wounds other than burns, and reserve its use for adults and children over 

Letter to professionals of health – Restriction of use of FLAMMAZINE(on the ANSM website, September 2019)

This topical article written by a scientific author reflects the state of knowledge on the subject treated at its publication. It is not a regularly updated comprehensive page. Subsequent developments in scientific knowledge may render it wholly or partly obsolete. Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection

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