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Home » Toradol Shot How does medication work? What are its effects 2022

Toradol Shot How does medication work? What are its effects 2022

Toradol Shot How does medication work What are its effects 2022

Toradol Shot How does medication work? What are its effects 2022

How does this medication work? What are its effects?

Ketorolac belongs to the class of medications called nonsteroidal anti-inflammatory drugs or NSAIDs. It is used for the short-term treatment (5 to 7 days) of acute pain caused by injuries, dental problems or treatments, surgery, or childbirth. The injectable form of this drug should not be used for more than two days to treat moderate to severe post-surgical pain. Ketorolac works by reducing the amounts of a substance produced by the body that causes inflammation and pain.

This medication is available under various brand names or in different presentations. A specific brand of this drug may not come in all forms or be approved for all conditions discussed here. Also, some forms of this medication may not be used for all of the conditions mentioned in this article.

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Your doctor may have suggested this medication for a condition not listed in this medication information article. If you haven’t discussed this with your doctor yet, or you’re not sure why you’re taking this medication, check with your doctor. Do not stop taking this medication without consulting your doctor first.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medicine could harm people for whom it was not prescribed.

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What forms does this medication come in?

Injection

Each mL of clear, slightly yellowish, sterile solution contains ketorolac tromethamine 10 mg. Nonmedicinal ingredients: 10% w/v alcohol and sodium chloride in sterile water. The pH is adjusted with sodium hydroxide or hydrochloric acid.

How should this medicine be used?

The usual dose of oral ketorolac for an adult is 10 mg taken every 4 hours or 6 hours, depending on the intensity of the pain. Daily doses above 40 mg are not recommended. Take this medication with meals or a snack to reduce the risk of having an upset stomach. After taking medicine, sit or stand for 15 to 30 minutes to further reduce the possibility of stomach acid irritating your throat.

The drug should be used for up to 5 days to treat postoperative pain and up to 7 days to treat pain due to injury. The lowest effective dose should be used for pain management. Ketorolac usually starts to work within an hour of taking it, but some people need to wait up to 24 hours to see its effects. If your pain does not improve, contact your doctor.

This medication should be used for the shortest possible treatment period.

Ketorolac is also used as a solution for injection in hospitals. The usual recommended dose is between 10 mg and 30 mg injected into a muscle for treatment lasting up to 2 days.

Several factors can be taken into account to determine the dose a person needs: their weight, their state of health, and the taking of other medicines. If your doctor has recommended a dose other than those listed here, do not change how you take medicine without consulting your doctor first.

This medicine must be used exactly as prescribed by your doctor. If you miss a dose, take medicine as soon as you remember and resume treatment as soon as possible. If it is almost time for your next dose, don’t worry about the missed dose and return to the usual dosing schedule. Do not use a double dose to make up for a missed dose. If you are unsure of what to do after missing a dose, ask your doctor or pharmacist for advice.

Store this medicine at room temperature, and protect it from light and out of the reach of children.

Do not dispose of medicines in the wastewater (e.g., not in the sink or the toilet bowl) or with the household waste. Ask your pharmacist how to dispose of unused or expired medicines.

In which cases is this drug not recommended?

Do not use this medicine in the following circumstances:

  • a feeling of general malaise;
  • breast-feeding;
  • an allergy to ketorolac or any ingredient in this medication;
  • an allergy to ASA or other anti-inflammatory drugs (e.g., ibuprofen, naproxen, diclofenac) or a history of allergic symptoms (e.g., runny nose, polyps in the nose, asthma, itchy skin) attributable to these drugs;
  • a current pregnancy (3rd trimester);
  • greatly reduced liver function or liver disease;
  • Reduced kidney function or risk of kidney failure.
  • significant uncontrolled heart failure;
  • surgery that is about to take place or has just taken place;
  • inflammatory bowel disease (e.g., ulcerative colitis, Crohn’s disease);
  • bleeding problems or bleeding in the brain;
  • current use of other NSAIDs (eg ibuprofen, naproxen, diclofenac);
  • during the period of labor or childbirth;
  • taking probenecid;
  • taking pentoxifylline;
  • high potassium in the blood;
  • a recent coronary artery bypass graft operation;
  • tiredness;
  • headaches;
  • loss of appetite;
  • A gastric or intestinal ulcer or a history of recurrent ulcers.

What are the possible side effects of this medication?

Many medications can cause side effects. A side effect is an adverse response to a drug when taken in normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

At least 1% of people taking this medication have reported the following side effects. Many of these side effects are manageable, and a few may go away on their own over time.

Consult your doctor if you experience these side effects and if they are severe or bothersome. Your pharmacist may be able to advise you on what to do if these side effects appear:

  • drowsiness;
  • burning or pain at the injection site;
  • a bruise at the injection site;
  • an upset stomach;
  • dizziness;
  • diarrhea;
  • indigestion;
  • nausea;
  • increased sensitivity of the skin to solar radiation;
  • Vomitings.

Check with your doctor as soon as possible if any of the following side effects occur:

  • the confusion;
  • the Depression;
  • swelling of the lower legs, ankles, or feet;
  • a rash or itching;
  • a fever;
  • increased blood pressure;
  • skin mottled with small red dots;
  • signs of a clotting disorder (e.g., unusual nosebleed, bruising, blood in the urine, coughing up blood, bleeding gums, cuts that won’t stop bleeding) ;     
  • signs of kidney problems (e.g., increased urination at night, decreased urine output, blood in urine, painful or difficult urination);
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools );
  • hearing disorders;
  • blurred vision;
  • Vomiting or persistent indigestion, nausea, stomach pain, or diarrhea.

Stop taking the drug and seek medical attention immediately if a response such as:

  • chest pain;
  • signs of a serious allergic reaction (e.g., hives, difficulty breathing, facial swelling, swelling of the mouth, throat, or tongue);
  • signs of meningitis that are not of infectious origin (e.g., headache characterized by severe or throbbing pain and accompanied by a stiff neck or stiff back);
  • Signs of stomach bleeding (e.g., bloody, black, or tarry stools, coughing up blood, vomiting blood, or material that looks like coffee grounds).

Some people may experience side effects other than those listed. Consult your doctor if you notice any symptom that worries you while using this medication.

Are there any other precautions or warnings?

Before using any medication, tell your doctor about any medical conditions or allergies you may have, the medications you use, and any other important facts about your health. Women should mention if they are pregnant or breastfeeding. These factors may influence how you should use this medicine.

HEALTH CANADA ADVISORY

JUNE 8, 2021

Health Canada has issued new warnings regarding nonsteroidal anti-inflammatory drugs (NSAIDs). To read Health Canada’s full advisory, visit Health Canada’s website at www.hc-sc.gc.ca.

Other advisories were also issued regarding nonsteroidal anti-inflammatory drugs (NSAIDs) on October 30, 2020.

Fertility: Like other NSAIDs, this drug can make it harder for a couple to conceive when a woman is taking ketorolac. Stopping taking the drug allows the body’s biochemical processes to return to normal, and the problem of procreation is often solved. 

Liver function: This medication may affect your liver function or cause liver problems. Contact your doctor immediately if you experience symptoms suggestive of liver problems (e.g., nausea, vomiting, fatigue, yellowing of the skin, or the whites of the eyes). If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any medical supervision is needed. Specific. People with severely reduced liver function and those with active liver disease should not take this medication.

Toradol Shot How does medication work? What are its effects 2022

Toradol Shot How does medication work? What are its effects 2022

Kidney function: Kidney disease or decreased kidney function may cause this medication to build up in the body and cause side effects. This medication may also affect kidney function. Seniors, people using diuretics (i.e., pills that increase urine excretion such as hydrochlorothiazide, furosemide), or those with a pre-existing kidney condition, liver or heart failure are at increased risk of kidney problems. Your doctor will monitor your kidney function with blood tests if you are taking this medication.

Infection: Using this medication may mask some signs of infection, such as fever or muscle aches. Contact your doctor if you notice other infection symptoms (e.g., painful or frequent passing of urine, sore throat, cough).

Heart disease: Use of this medication may cause fluid retention, which will worsen symptoms of some heart conditions. If you have heart failure, high blood pressure, or other medical conditions that increase your risk of fluid retention (e.g., kidney problems), discuss with your doctor how this medication may affect your medical condition, the influence of your medical condition on the administration and effectiveness of this medicine, and the need for any special monitoring.

Toradol Shot How does medication work? What are its effects 2022

Blood pressure: Like other NSAIDs, ketorolac can cause an increase in blood pressure that may contribute to another heart condition. If you have high blood pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any further specific medical supervision.

Heart problems:  Like other NSAID medications, ketorolac may increase the risk of heart attack, stroke, or blood clots. If you have any risk factors for heart problems such as high blood pressure, high cholesterol, diabetes, peripheral arterial disease, heart failure, or coronary artery disease, discuss with your doctor how this medication might affect your medical condition, how your medical condition affects the dosing and effectiveness of this medicine, and whether any special monitoring is needed.

Allergic reactions: You should not take this medicine if you have reacted to acetylsalicylic acid (ASA) or another NSAID (e.g., ibuprofen, ketoprofen, diclofenac) in the past that has included a runny nose; itchy rash, polyps in the nose, shortness of breath and wheezing. If symptoms of an intense allergic reaction appear (e.g., hives, difficulty breathing, wheezing, puffiness of the face, swelling of the tongue or throat), seek medical attention immediately.

Toradol Shot How does medication work? What are its effects 2022

Bleeding: ketorolac may reduce the ability of blood platelets to stick together. It can make bleeding from cuts harder to stop. If you have a condition that reduces the clotting properties of your blood, or if you are taking medicines to prevent blood clotting, discuss with your doctor how this medication may affect your medical condition, how your condition on the administration and effectiveness of this medicine, and the relevance of any specific medical supervision.

If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or dark, tarry stools, report it to your doctor as soon as possible. Your doctor will order regular blood tests to ensure that any potential problems are caught early.

Drowsiness and dizziness: This medication may cause drowsiness or dizziness. Avoid driving, operating machinery, or doing other tasks that require mental alertness until you have determined the effect of this medication on your mental coping skills.

Urinary symptoms: This medication may cause symptoms such as frequent or painful passing of urine and blood in the urine. Stop taking this medication and contact your doctor immediately if these symptoms occur.

Toradol Shot How does medication work? What are its effects 2022

Stomach and intestinal ulcers and bleeding: This medication may cause stomach ulcers and bleed. These complications can occur at any time and are sometimes serious.

If you have diverticulosis, Crohn’s disease, ulcerative colitis, or stomach or intestinal ulcer, discuss with your doctor how this medication may affect your medical condition, how your medical condition affects your administration and efficacy of this medicinal product and the need for specific medical supervision.

If you experience symptoms of an ulcer or other stomach-related problems (e.g., stomach or abdominal pain, dark stools, vomiting bloody or like coffee grounds, weakness), contact your doctor immediately or seek medical attention as soon as possible.

Prolonged use: long-term treatment with ketorolac (beyond 5 or 7 days in the form of tablets or two days in the form of injections) is not recommended because the risk of side effects would increase proportionally to the duration of the treatment.

Toradol Shot How does medication work? What are its effects 2022

Potassium levels: Ketorolac may also cause high blood potassium levels. The risk of having high potassium levels in the blood is greater for the elderly, people with diabetes or kidney failure, or using beta-blockers (e.g., metoprolol, atenolol), inhibitors of angiotensin-converting enzymes, or ACE inhibitors (e.g., ramipril, enalapril), or diuretics (e.g., triamterene, amiloride). Because extremely high potassium blood levels can contribute to other conditions such as certain heart problems, your doctor will monitor your potassium levels with blood tests while you are taking this medication.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If pregnancy occurs while using this medicine, contact your doctor immediately. It should not be used during the last three months of pregnancy as it can cause heart and kidney problems in the developing baby and lengthen the labor period and cause excessive bleeding in the mother during childbirth.

Toradol Shot How does medication work? What are its effects 2022

Breast-feeding: This medication passes into breast milk. If you use ketorolac while breastfeeding, your baby may feel the effects. It is not recommended to breastfeed your child while taking ketorolac.

Children: Neither the safety nor the effectiveness of this medication has been established for children and adolescents under 18 years of age.

Seniors: This medication may put seniors at greater risk of side effects. Seniors will be subject to strict medical monitoring targeting side effects, and their doctor may prescribe a lower dose than is usually recommended.

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Can other agents interact with this drug?

There may be an interaction between ketorolac and any of the following agents:

  • acetylsalicylic acid (ASA);
  • omega-3 fatty acids;
  • alcohol;
  • aliskiren;
  • alteplase;
  • aminoglycosides (eg amikacin, gentamicin, tobramycin);
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine);
  • apixaban;
  • beta-blockers (eg atenolol, metoprolol);
  • bimatoprost;
  • bisphosphonates (eg alendronate, etidronate);
  • angiotensin receptor blockers (eg candesartan, irbesartan, losartan);
  • clopidogrel;
  • colesevelam;
  • colestipol;
  • corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone);

Toradol Shot How does medication work? What are its effects 2022

  • cyclosporine;
  • dabigatran;
  • dasatinib;
  • other nonsteroidal anti-inflammatory drugs or NSAIDs (e.g., naproxen, diclofenac, ibuprofen);
  • deferasirox;
  • quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin);
  • desmopressin;
  • digoxin;
  • dipyridamole;
  • diuretics (eg spironolactone, furosemide, hydrochlorothiazide);
  • edoxaban;
  • eplerenone;
  • glucosamine;
  • haloperidol;
  • heparin;

Toradol Shot How does medication work? What are its effects 2022

  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin);
  • hydralazine;
  • angiotensin-converting enzyme inhibitors or ACE inhibitors (captopril, enalapril, ramipril);
  • selective serotonin reuptake inhibitors or SSRIs (e.g., paroxetine, citalopram, escitalopram);
  • selective serotonin-norepinephrine reuptake inhibitors or SNRIs (e.g., desvenlafaxine, duloxetine, venlafaxine);
  • latanoprost;
  • lithium;
  • mesalazine;
  • methotrexate;
  • multivitamins;
  • pemetrexed;
  • pentoxifylline;
  • sodium phosphates;
  • prasugrel;
  • probenecid;
  • herbal products that alter blood clotting (e.g., cat’s claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, Turmeric);
  • rivaroxaban;
  • sulfasalazine;
  • potassium supplements;
  • tacrolimus;
  • tenofovir;
  • ticagrelor;
  • ticlopidine;
  • tipranavir;
  • vancomycin;
  • Vitamin E;
  • warfarin;

If you are taking any of these medicines, consult your doctor or pharmacist. In your case, your doctor may ask you to:

  • stop taking any of the drugs;
  • replacing one of the drugs with another;
  • change the way you take one or both of the medicines;
  • change nothing at all.

The interference of one drug with another does not always lead to discontinuing taking one of them. Ask your doctor what to do in case of drug interactions.

Medications other than those listed above may interact with this medication. Tell your doctor about everything you take, including prescription and over-the-counter medications and herbal remedies. Do not forget to mention any supplements you take. If you consume caffeine, alcohol, nicotine, or illicit drugs, you should inform your prescribing doctor since these substances can modify the action of many drugs.

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